Thursday, 21 September 2017

Amplify Your PCR Success with the Right PCR Instrument!

Amplify Your PCR Success with the Right PCR Instrument! 

Nowadays, almost every biology lab has a PCR instrument — from portable, battery-operated machines, to “PCR-by-water baths”, do-it-yourself PCR, or familiar vendor packages, including those with real-time quantification or droplet digital capabilities, DNA amplification depends on a robust thermal cycler. If you are looking to upgrade, add to, or even replace the lab’s current PCR…

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Tuesday, 19 September 2017

How UV Radiation Causes DNA Mutations

How UV Radiation Causes DNA Mutations 

We all know that we are supposed to put on sunscreen in the summer months to protect ourselves from skin cancer, and the connection between sun exposure and cancer is well documented (Koh et al., 1996; Armstrong and Cust, 2017). UV-A and UV-B rays from the sun interact with the DNA in our skin and…

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Sunday, 17 September 2017

What to Do During That Awkward One-Minute Spin

What to Do During That Awkward One-Minute Spin 

We’ve all been there. Twiddling our thumbs. Staring off into space. Pacing back and forth. This is the dreaded one-minute spin. If you’ve dabbled in molecular biology, you’ve likely encountered this awkward time. Not exactly enough time to actually do anything else, but when you’ve got nothing to do but wait, one minute seems like…

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Thursday, 14 September 2017

The Trouble with Disease Models: Case Study in Diabetes

The Trouble with Disease Models: Case Study in Diabetes 

The development of new drugs requires reliable and robust animal disease models. Since the cause of many diseases is still unknown, it is often difficult to identify adequate and predictive disease models. For example, researchers developing treatments for neuropsychiatric diseases such as Parkinson’s and Alzheimer’s face a particular challenge given the subjectivity of many of…

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Wednesday, 13 September 2017

5 Digital Tools to Increase Your Productivity in Research

5 Digital Tools to Increase Your Productivity in Research 

Scientific research is a constant battle against time. Whether it is your Masters, PhD or Postdoc, you always feel the pressure to generate data for external validation. For that, you need to spend your time on the bench and not at the desk, but that can be hard. Unfortunately, non-laboratory tasks occupy a large segment…

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Tuesday, 12 September 2017

How to Prepare Biological Metallo-Proteins

How to Prepare Biological Metallo-Proteins 

The first thing one might notice when working with metallo-proteins is that they offer unique, colorful reactions.  These colorful reactions are based not only on the metal, but the ligand, or coordinating molecules.  Approximately 80% of proteins contain inorganic cofactors like iron (Fe) and copper (Cu) metals necessary to catalyze a reaction.  Understanding how these…

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Post-sorting Checks and Measures

Post-sorting Checks and Measures 

In my previous article I discussed steps you can implement to ensure that a sample is ready for cell sorting. But now it’s time to make sure the sort worked. Here are a few sorting checks and measures to ensure that all’s well that ends well. Post-sorting Checks and Measures Re-evaluate Your Catch Tubes Sorting…

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