Wednesday 27 May 2020

Why You Should Consider Adding CRISPRa and CRISPRi to Your Toolbox

Find out how CRISPR-mediated gene activation (CRISPRa) and repression (CRISPRi) works and why you should consider using them in addition to your CRISPR knockouts.

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Tuesday 19 May 2020

How CRISPR Can Be Used to Detect Emerging Viral Pathogens

The threat of pandemic viruses can be mitigated by developing diagnostic tests that are rapidly implementable and field deployable. Two CRISPR-based strategies, DETECTR and SHERLOCK, have been developed recently that not only meet these criteria but offer unprecedented multiplexing capabilities. This article discusses the theoretical basis of proposed and currently available viral diagnostics for educational…

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Thursday 14 May 2020

A Guide to Gradient Gels: The Why’s and How’s

Fret no more over fuzzy bands! We uncover how gradient gels can give you better results, and maximize your precious samples when performing SDS-PAGE

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Wednesday 13 May 2020

A CRISPR Approach to Immuno-Oncology

T cells can be tricky to engineer with CRISPR. Find out the key considerations when editing these cells and how you can overcome any associated challenges.

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Thursday 7 May 2020

Online Learning Resources for Scientists Working From Home

From bad weather to rail strikes or global pandemics, there are several reasons you may find yourself working from home. After writing up any outstanding grant proposals or papers, reviewing the literature, and perusing the endless field of coronavirus news updates, what’s a scientist to do? Brush up on your non-lab skills, of course! We…

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Wednesday 6 May 2020

How to Understand CRISPR Formats and Their Applications

Find out how modified variants of CRISPR nucleases provide gene editing with reduced off-target effects and can even control gene expression without altering the DNA sequence.

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